Minneapolis ( (listen)) is the largest and most populous city in the U.S. state of Minnesota and the seat of Hennepin County, the state's most populous county. As of 2019, Minneapolis has an estimated population of 429,606, making it the 46th-largest city in the United States, the 8th-largest in the Midwestern United States, and the second-most densely populated large city in the region behind Chicago. Minneapolis and its neighbor Saint Paul make up the Twin Cities, with Minneapolis being the larger of the two. The Twin Cities metro and their surrounding suburbs contain about 3.64 million people, making it the third-largest economic and population center in the Midwest and the 16th-largest metropolitan area in the United States.Minneapolis lies on both banks of the Mississippi River, just north of the river's confluence with the Minnesota River, and adjoins Saint Paul, the state's capital. The city is abundantly rich in water, with 13 lakes, wetlands, the Mississippi River, creeks and waterfalls; many connected by parkways in the Chain of Lakes and the Grand Rounds National Scenic Byway. Due in part to its high degree of accessibility, the city is often ranked as having one of the best park systems in the United States. Minneapolis was once the world's flour milling capital and a hub for timber. The city and surrounding region is the primary business center between Chicago and Seattle, as well as the largest urban population area between the two cities. Minneapolis is home to five Fortune 500 companies, and the Twin Cities are the fifth-largest hub of major corporate headquarters in the United States. Minneapolis has the fourth largest percentage of the LGBT people in the U.S. Noted for its strong music and performing arts scenes, Minneapolis is home to both the award-winning Guthrie Theater and the historic First Avenue nightclub. Reflecting the region's status as a center of folk, funk, and alternative rock music, the city served as the launching pad for several of the 20th century's most influential musicians, including Bob Dylan and Prince. Minneapolis has also become noted for its underground and independent hip-hop and rap scenes, producing artists such as Lizzo, Brother Ali, Atmosphere, and Dessa. Renowned for its investment in biking infrastructure, the city is frequently ranked as one of the best cities in the United States for biking.